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Description

[1] Systematic reviews and meta-analyses of randomized controlled trials report that retatrutide produces substantial reductions in body weight in adults with obesity, with mean percentage weight loss typically between 15 and 24 percent over 48 to 72 weeks, depending on study protocols and populations

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The STEP 4 withdrawal trial showed that most participants regained approximately two-thirds of lost weight within one year of discontinuation, confirming that semaglutide treats obesity chronically rather than curing it

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Patients with active gout or severe uric acid disorders should continue allopurinol, febuxostat, or other urate-lowering drugs prescribed by their rheumatologist or primary care provider

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